The health benefits of Lingzhi have been well known for over 50 years. More than 2,000 Ganoderma lucidum papers have been published in international journals, 90% of which are related to water extracts or alcohol extracts of Ganoderma fruiting bodies. In fact, the efficacy of Ganoderma, which is widely recognized by scientists and is generally understood and felt by people, comes from the water extract or alcohol extract of the fruiting body of Ganoderma lucidum.
The main ingredient in the water extract is Ganoderma polysaccharide, and the main ingredient in the alcohol extract is Ganoderma triterpene. Either Ganoderma polysaccharide or Ganoderma triterpene is a "collective" of "a group of" similar substances. The properties of these two major active ingredients are very different: Ganoderma polysaccharide is water-soluble, mainly composed of monosaccharides and a small amount of protein, and the molecular weight is hundreds of thousands to millions, can only be used as a passer-by, after stimulating countless immune cells on the intestinal wall, the polysaccharides will be excreted to the outside of the body. Ganoderma triterpene is fat-soluble natural hydrocarbon with a molecular weight of 500 or so, which can be absorbed into the blood circulation by the intestines.
Because of the different chemical structures, the mechanism of action is different, but what is interesting is that the two often have the same health benefits.
At the 9th International Conference on Mushroom Biology and Mushroom Products 2018, two experts reported that the Ganoderma fruiting body water extract (polysaccharide) and alcohol extract (triterpene) both have a preventive effect on the same disease.
Liu bin, a professor at Fujian Agricultural and Forestry University, extracted the fruiting body of Ganoderma lucidum with 55% and 95% ethanol respectively, and then extracted the fruiting body of Ganoderma lucidum with hot water to explore the preventive effect of alcohol extract and water extract on the abnormal lipid metabolism induced by high fat and sugar.
The results showed that both the alcohol extract and the water extract of Ganoderma lucidum fruiting body inhibited the increase of blood lipids, inhibited the accumulation of liver fat, and regulated the "intestinal bacteria flora" and "liver gene".
The report of Malaysia's Alok Nahata focuses on the prevention of prostate hyperplasia by Ganoderma lucidum . The researchers administered 10, 20 or 50 mg/kg of Ganoderma lucidum fruiting body alcohol extract or water extract orally daily while administering testosterone to rats. After 28 days, the ratio of prostate gland weight and body weight in rats and the PSA value positively correlated with prostatic hyperplasia in serum were significantly closer to normal than those without Ganoderma lucidum, and the effect was proportional to the dose, showing either the alcohol extract or water extract of Ganoderma lucidum fruiting body has the effect of preventing prostate hyperplasia.
Unlike many pharmacological experiments in the past, which only discussed the water extract or alcohol extract of Ganoderma lucidum, these two reports showed the preventive effect of both on the same disease. The biggest hint it brings to us is that the best way to give full play to the health value of Reishi Mushroom should be the addition of "water extract + alcohol extract from Ganoderma lucidum fruiting body".Without one of them, there may be no "more with less" effect.