Ganoderma Lucidum Extract Can Relieve Autoimmune Hepatitis Effectively

- Jun 16, 2017 -

Recently, China's Wuhan Huazhong Agricultural University in the "Journal of Ethnopharmacology" (folk medicine journal) published a report pointed out that Ganoderma lucidum spore powder in the triterpenoid Ganoderma lucidum, Ganoderma lucidum polysaccharide peptide, Ganoderma lucidum peptide compounds with significant liver activity.


The mice were randomized to receive three groups of Ganoderma lucidum spores of Ganoderma supplier once a day for two weeks at doses of 60, 120 and 180 mg / kg, while mice in the control group were fed with physiological saline One group is the control group that represents the normal mouse.


Two weeks later, all mice except the control group were injected intraperitoneally with D-galactosamine (750 mg / kg). This substance will stimulate the immune system to produce a large number of antibodies to attack the liver cells, causing autoimmune hepatitis (or immune liver injury), very similar to the occurrence of human violent hepatitis.


Therefore, as a control group of mice, not only serum GOT, GPT index increased, liver tissue also appeared in a high concentration of lipid peroxide product - malondialdehyde, and antioxidant capacity related to superoxide dismutase (SOD) activity and glutathione (GSH) concentration was significantly reduced, indicating that the liver is suffering from severe oxidative damage, and thus a negative impact on liver function.


However, mice with Ganoderma lucidum spore powder protection are much better, especially in mice given high doses (180 mg / kg) of GLP, whether serum GOT, GPT, or pathological features of liver tissue Normal mice are very similar, indicating that Ganoderma lucidum spore powder on autoimmune hepatitis has a very good protective effect.


Although there are few reports on the active peptides of Ganoderma lucidum spore powder, it has been pointed out that these components not only have antioxidant activity and regulate blood glucose function, but also improve the survival time of asphyxia in mice, Liver effect, can not help but make one of the eyes bright.


From the general nutritional point of view, by the amino acid composition of the polypeptide material, into the body will be digested and digested by the gastrointestinal transformation, to maintain the normal physiological operation of nutrients, but from Ganoderma lucidum spore powder active peptide can play a physiological activity, Obviously there are many unknown areas of Ganoderma lucidum spores waiting for scientists to dig and answer.