Turkey: Ganoderma Lucidum Polysaccharide Protects Spinal Nerves And Reduces Traumatic Spinal Cord Injury

- Aug 24, 2018-

The spinal cord is a part of the central nervous system and is connected to the brain and peripheral nervous system. Therefore, when the external force hurts the spinal cord and causes a traumatic spinal cord injury, there may be problems with movement, sensation, and dysfunction of the bowel movement.


Traffic accidents are the most common cause, followed by accidental falls (common in the elderly) and violence, sports injuries (common in children and adolescents), and occupational injuries (common in adults in the construction industry). Although such misfortunes may occur in all ages, most of the injuries occur in young men from teens to twenties.

Although studies in the past have pointed out that Ganoderma lucidum can protect nerve cells from oxidative damage, there is no relevant discussion on traumatic spinal cord injury. In November 2015, a report published in the "Injury" research journal brought us good news thanks to the collaboration jointly conducted by experts of neurosurgery, biochemistry, pathology, and emergency medicine from Turgut Ozal University and Yuksek Ihtisas Hospital in Turkey, who carried out the experiments with eight-month-old young male rats.

They were randomly divided into five groups, eight in each group: the normal control group (no surgery), the false experimental control group, trauma group, the Ganoderma lucidum polysaccharide group, and the steroid group. In the sham-operated control group, only laminectomy was performed, and the spinal cord and nerve were not injured. In the trauma group, the Ganoderma lucidum polysaccharide group, and the steroid group, the rat T7 spinal cord was clamped by an aneurysm for 1 minute, causing traumatic spinal cord injury.


Rats in the Ganoderma lucidum group were given 400 mg/kg of Ganoderma lucidum fruit body polysaccharide extract daily from the day before surgery until they were sacrificed. In the steroid group, 30 mg/kg of steroid drug (methylprednisolone) was administered intraperitoneally immediately after surgery.

Twenty-four hours after surgery, the BBB scoring method (Basso, Beattie, Bresnahan locomotor scale) was used to assess the recovery of hindlimb motor function in rats, and the rat limb muscle strength was evaluated by the inclined-plane test. The rats were sacrificed to detect the index related to inflammatory response and oxidative stress in the spinal cord tissue, and the pathological changes of the spinal cord tissue sections were observed, and the ultrastructure of the spinal cord was observed by Transmission Electron Microscopy.

Experiments have shown that after traumatic injury of the spinal cord, the activity of caspase-3, the concentration of tumor necrosis factor (TNF-α), the activity of bone marrow peroxidase (MPO), the concentration of malondialdehyde (MDA), and The concentration of nitric oxide (NO) will increase significantly, but these indices are relatively low in the Reishi Mushroom polysaccharide group and the steroid group, indicating that Ganoderma lucidum polysaccharides and steroids have the effect of reducing inflammation and oxidative stress, which is a good phenomenon for repairing spinal cord injury.

In addition, both histopathological sections and ultrastructural analysis showed that the Ganoderma lucidum polysaccharide group and the steroid group can alleviate the degree of spinal cord injury in rats. Interestingly, Ganoderma lucidum polysaccharides and steroids, which are comparable in reducing inflammation and oxidative stress, have a gap in the maintenance of the spinal cord—there are more normal nerve cells and fewer lesions in the Ganoderma lucidum polysaccharide group than in the steroid group. For this reason, the hindlimb exercise capacity and limb muscle strength of the spinal cord of the Ganoderma lucidum group were the best in all groups.

The above experimental results preliminarily prove that Lingzhi polysaccharide can play a protective role for traumatic spinal cord injury. To some extent, it may also explain why some car accident patients take Ganoderma lucidum immediately after the accident, which can accelerate the recovery of the body. However, the researchers also said at the end of the report that there are still some restrictions on the animal experiment, including the number of "eight in each group", which can amplify the experimental results. If there are further experiments in the future, more mouse contributions may be needed.

In addition, this experiment focuses on the protective effect of Ganoderma lucidum polysaccharides on spinal cord injury in the early stage of trauma. If the experiment time is lengthened, what will happen? It is worthwhile to find out. Finally, the experimental design is to start feeding the rats with Ganoderma lucidum polysaccharides seven days before the spinal cord injury. If the Ganoderma lucidum polysaccharides are eaten after the trauma, can they play the same role? We hope that in the near future, there will be more experiments to tell us the answer.


This article reprinted from Lingzhi News Network