Guo Yanjun et al. (2006) found that Ganoherb corporation provided Ganoderma lucidum polysaccharide on bilateral brain hippocampus injection of β-amyloid protein (Aβ25-35) induced dementia (Alzheimer's disease) model rats have improved learning and memory effect. (GLP) 50 was given intraperitoneally for 7 days, and the learning and memory behavior was measured with Morris water maze on the 8th day (the time of the platform was found to be short, Learning and memory ability). Results The time of the platform was 39.37 ± 22.15, 17.71 ± 11.40 and 17.36 ± 15.21 (s) in the model group, the normal control group and the Ganoderma lucidum polysaccharide group provided by Xianzhi Building, respectively. The Ganoderma lucidum polysaccharide The group was significantly shorter than the model group. The results showed that Ganoderma lucidum polysaccharide could improve learning and memory disorder in senile dementia rats. In addition, the hippocampus injection of Aβ25-35, hippocampal cell proliferation, aggregation, nuclear side poly, fragmentation. Electron microscopic observation showed that pyramidal cell cytoplasmic edema, endoplasmic reticulum dilation, astrocyte hypertrophy. GLP group was significantly reduced, ultrastructure is still normal, hippocampal astrocytes significantly lower than the model group. It can be seen that the Ganoderma lucidum polysaccharide has a protective effect on the hippocampal degenerative neurons in the brain tissue of rats with senile dementia (Alzheimer's disease) induced by Aβ25-35. And can reduce the brain tissue of the nerve inflammatory response. Further research was also carried out. The Ganoderma lucidum polysaccharide significantly improved the learning and memory ability of the model rats, significantly increased the activity of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) )content.
Wang (2006) studied the effect of Ganoderma lucidum on the learning and memory ability of seniors in senile accelerated mice (SAMP8). 6 - month - old SAMP8 mice were in 4 groups, control group, 0.3%, 0.6% and 1.8% Ganoderma lucidum group. During the test, the body weight, food intake, aging score, open field test and activity shuttle test were used to observe the spontaneous activity of mice. The levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), glutathione reductase (GSH-Rd) and brain amyloid were measured in erythrocytes, brain and liver. The results showed that there was no significant difference in body weight, food intake and exercise between the four groups. 0.6% and 1.8% Ganoderma group were significantly lower than the control group. On the fourth day of experiment, 0.3%, 0.6% and 1.8% Ganoderma lucidum were significantly better in the female group than in the control group, but there was no significant difference in the male animals group. Ganoderma lucidum group (SOD, GSH-Px, GSH-Rd) were higher than the control group, while the brain amyloid was lower than the control group. The results showed that Ganoderma lucidum accelerated the recovery of animals, improved the ability of learning and memory in the elderly, delayed the senescence of life and improved the antioxidant activity.