Can Ganoderma Lucidum Lose Weight?

- Apr 10, 2017-

many media have reported the 'Ganoderma help lose weight' message, carefully looking for the source of news content will be found, mainly and "Nature Communications" published in a June 23 study related. The report pointed out that animal experiments confirmed that 'Ganoderma mycelium water extract' and its 'polymer polysaccharide' can regulate the intestinal bacteria phase, reduce the weight of mice due to high fat diet. So the conclusion should be, diet does not change, eat Ganoderma lucidum or fat, but not so fat.


This is the international attention of the new scientific discovery, is the Chang Gung University Professor Lai Xinzhi and others efforts for many years of research results. In fact, they are in the experiment from the inflammatory response, insulin resistance and other indicators observed, the diet may be due to the involvement of Ganoderma lucidum ingredients and 'fat more healthy', but it is interesting place.





'Ganoderma helps lose weight!' 'A few days ago (June 24 to 26), this or similar title captured the major domestic media layout, and even attracted foreign media attention (1-3). On the one hand, the research results were published on June 23 in Nature Communications, a sub-brand of the top international scientific journal Nature, 11.47; on the other hand, of course And 'weight loss' this trend related issues.


Can care for immunity, anti-tumor, heart and liver Ganoderma lucidum, really can lose weight? lose weight? Or as some media describe 'shovel' Looking back at the British BBC NEWS release the title of this message, Mushroom used in Chinese medicine 'slows weight gain', perhaps more close to the results of this study of Ganoderma lucidum - to reduce weight gain.





Ganoderma mycelium water extract slows the diet caused by obesity


The report, titled 'Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota', is reported by Changchun University Medical Biotechnology & Test Professor Lai Xinzhi and other people published, mainly in the study of Ganoderma mycelium water extract (a water extract of Ganoderma lucidum mycelium, the author referred to as WEGL) for high fat diet caused by obesity, and often accompanied by obesity from insulin Resistance (cell is insensitive to insulin and lead to elevated blood sugar) (4).


The researchers used 8 weeks of normal male mice as the experimental object, after 8 weeks of experiments found that eating the general feed (total calories 13.5% from fat) mice, with or without additional WEGL, weight gain almost There was no difference, averaging from 24 grams to 28 grams. In contrast, the average body weight was increased to 42 grams with a high fat diet (60% of total calorie from fat), but if a high concentration of WEGL was given at the same time (8% (w / v) WEGL Of the aqueous solution of 100 μg / L], the average body weight will only be increased to 35 grams.


Although 35 grams less than 42 grams of body weight less 7 grams (16.7%), but compared to the normal 28 grams or much higher. So, WEGL can not change the 'fat diet caused by obesity' fact, can only reduce the weight increase. (The above data is projected from the graphs in Figure 1 and Figure b of the report, which did not show data on the weight change of the mice directly in the article)



Improve the high-fat diet caused by inflammation, insulin resistance and blood sugar


More worthy of attention, but WEGL for inflammation and insulin resistance to improve. Obesity-induced chronic inflammation and insulin resistance are important factors that contribute to the onset and worsening of type 2 diabetes. However, according to the experimental results, mice fed with high-fat diet + WEGL were able to escape obesity, but the liver and Adipose tissue inflammation index and the general diet is very close to normal mice, and after meals, insulin and blood glucose levels than the simple high-fat diet to improve the number of mice. The result seems to some extent suggest that WEGL can make the chubby rat 'fat more healthy'.



Regulate intestinal bacteria phase, protect the intestinal barrier


Similar results also occur in the improvement of intestinal tract phase and intestinal protection. In the past, many studies have confirmed that high-fat diet can cause the composition of intestinal bacteria composition disorders, including the two major intestinal bacteria 'Firmicutes (Bacter colon) / Bacteroidetes (Bacter colonet)' high proportion, while the other group will The release of endotoxin, Proteobacteria, also increases the number of strains of Escherichia coli.


The imbalance of these bacteria has been confirmed and the formation of obesity, but Lai Xinzhi and other animal experiments have shown that high-fat diet caused by obese mice if eating WEGL, the proportion and the number of bacteria will be adjusted to close to normal weight Of the mouse intestinal condition.


In addition, high-fat diet will undermine the integrity of the intestinal barrier, making the death of Gram-negative bacteria after the release of endotoxin (that is, the composition of bacterial cell wall lipopolysaccharide LPS) to pass through the intestinal barrier, into the blood Cycle, and then stimulate the release of immune cells immune cells, insulin resistance, and even accelerate the formation of obesity.


These problems seem to be resolved by WEGL, because animal experiments show that both obese mice with WEGL and high fat diet, both the integrity of the intestinal barrier, or the serum endotoxin content, are both small in the normal diet The same or very close.



Experiments confirmed that the adjustment of intestinal bacteria phase is the efficacy of WEGL source


In order to confirm that WEGL is through the 'regulation of intestinal bacteria phase' of the pipeline, high fat diet mice play a role in reducing weight gain, the team also conducted an experiment: first WEGL fed normal diet of mice and high fat Diet-fed obese mice were collected for four weeks, and the next two months of the mouse's feces were collected and treated with another group of mice fed with high-fat diet.


After eight weeks of experimentation, these 'pooons' can also reduce weight gain with WEGL, reduce the inflammatory response, adjust the intestinal bacteria phase, protect the intestinal barrier. This means that WEGL does help the growth of certain beneficial bacteria in the gut and suppresses the forces of some harmful bacteria, so when the bacterial structure is discharged with the feces and then into the intestine of another group of high-fat diets Play the same role.



More than 300,000 molecular weight polysaccharide is the main active ingredient


The researchers further analyzed the composition and activity of WEGL and found that more than 10% of the mycelial extract was composed of polysaccharides, in which the 'molecular weight of more than 300,000 polysaccharides' (about three percent of the whole polysaccharide) Reduce the effect of weight gain and the overall effect of the extract the closest, so this type of polysaccharide should be WEGL effective main components. Ganoderma lucidum polysaccharides can not be digested by the human digestive tract enzymes, but may become a source of intestinal bacterial growth, the researchers speculated that this type of polysaccharide is likely to be particularly beneficial to some of the beneficial bacteria.


In addition, according to the "Central News Agency" reported that the team was also unexpectedly found in the course of the experiment, WEGL can promote the intestinal Gram-negative bacteria under the growth of an anaerobic bacteria, the intestinal barrier is more robust, Of endotoxin from the intestine into the blood caused by obesity and inflammation. Because this is the first discovery of the scientific community, the team temporarily named it 'slimming bacteria', to be the next one or two years of its mechanism of action have a more clear understanding, that will publish the official name of the bacteria.



There is no shortcut to weight loss


Before that, there were also studies in Korea, Japan and the United States that (5-9), Ganoderma lucidum polysaccharides or triterpenoids extract can inhibit adipocyte differentiation and reduce fat content in adipocytes, but both are cell experiments As a result, this is the first time there are scientists with animal experiments show that Ganoderma lucidum mycelia water extract and its high molecular weight polysaccharide, can stimulate the growth of intestinal bacteria, reduce weight gain.


Mouse experiments can be true in the human body, to help obese people to improve intestinal ecology disorders and metabolic abnormalities, but also to be clinical trials to prove. But it is certain that WEGL is a mycelium extract of Ganoderma lucidum, which is neither the 'a Ganoderma lucidum', nor the 'no extract' of the mycelium of Ganoderma lucidum, which is often used by the public media. After a certain extraction process to get the ingredients.


More noteworthy is that the above results do not indicate that WEGL has a 'lose weight' effect because the experiment does not allow the 'fat mouse' to change the role of the 'mouse', nor can it prevent high fat diet induced obesity. As BBC reporter reminded in the news, do not think that the experiment in the extract added to the cola, you can help you lose weight! The world is not so magical things.


Therefore, when we are happy in the scientific community of Ganoderma have more understanding and affirmation, weight loss or rely on their own, and quit 'fat food' must be the key first step.