Study on the Prevention and Treatment of Pulmonary Fibrosis Caused by Anti - cancer Drugs by Ganoderma Polysaccharide

- Mar 10, 2017-

When the lung tissue fibrosis, the alveolar has lost the function of exchange of gas, a serious impact on breathing, almost no cure can be treated, the patient five years of survival is lower than lung cancer Therefore, unless the early lesions, that is, when the alveolar wall inflammation has been found, only to prevent or delay the deterioration of the chance of disease, once into the organization of fibrosis, the treatment is very difficult. Only the early breathing is not smooth, shortness of breath and dry cough often overlooked by patients or doctors misdiagnosed, so many patients often found that pulmonary fibrosis has often entered the late.


Smoking, gastroesophageal reflux, environmental effects, genetic, genetic mutations, drugs and other factors, may cause long-term lung injury and excessive inflammation of the situation, leading to the occurrence of pulmonary fibrosis. But if at the same time there are Ganoderma lucidum protection, may be able to resolve the crisis in the invisible.


Central South University, Xiangya Hospital, Department of Respiratory Medicine and a number of scientific research units to prove that Ganoderma lucidum polysaccharide can prevent the anti-cancer drug bleomycin bleomycin caused by pulmonary fibrosis, the results have been published in July 2016 "International Journal of Biological Macromolecules "(International Journal of Biomacromolecules).


The rats were given bleomycin by intragastric administration, followed by normal saline, prednisone (5 mg / kg daily) or polysaccharide extract of Ganoderma lucidum (100 mg / kg or 300 mg / Kg) for 28 days and compared with normal rats and rats injected with bleomycin but not treated.


Pulmonary fibrosis will increase the lungs due to disease (increased lung weight), rats will also be due to dyspnea affect appetite and weight loss, but given Ganoderma lucidum polysaccharides in rats, especially high-dose group, lung weight and weight Relatively close to normal rats, although the steroid group also has this effect, but the effect is not as obvious as the high dose of Ganoderma lucidum group.


In addition, Ganoderma lucidum can reduce the number of inflammatory cells infiltrated in the lungs and reduce the collagen secretion and hydroxyproline content in the lungs (collagen is a fibrous material, whereas hydroxyproline is synthetic collagen Major amino acids), thereby reducing the severity of lung inflammation and pulmonary fibrosis. And whether low or high doses of Ganoderma lucidum polysaccharides, the effect is better than steroids, of course, high-dose Ganoderma lucidum polysaccharide effect is more significant.


The pathogenesis of pulmonary fibrosis is complex, but it is certain that free radicals cause oxidative damage to play a key role in it. According to the study, Ganoderma lucidum can increase the levels of glutathione (GSH), glutathione peroxidase (GSH-Px), catalase, superoxide dismutase (SOD) And other antioxidant protective enzyme content, while reducing the cells by the oxidation damage (less oxidation of MDA products). This shows that the protective effect of Ganoderma lucidum polysaccharide, some from the "enhance the antioxidant capacity of the lungs."


The results of this study not only prove that Ganoderma lucidum polysaccharide can prevent the occurrence of pulmonary fibrosis, but also to remind the use of bleomycin cancer patients, the feasibility of Ganoderma adjuvant therapy.


This is commonly used to treat head and neck cancer, lymphoma and testicular cancer traditional drugs, the treatment seems to be good, there are 5 to 10% chance of pneumonia and pulmonary fibrosis may cause. In order to avoid further development to difficult to restore pulmonary fibrosis, usually with drugs (such as steroids) to inhibit the occurrence of pneumonia. However, steroids will suppress the immune function, and is not conducive to anti-cancer, then switch to Ganoderma lucidum polysaccharide, may be able to provide better protection of the lungs, but also help to inhibit tumor growth and reduce the other side effects of drugs ?